Predicted to enable NEDD8 activating enzyme activity; protein heterodimerization activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including mitotic DNA replication checkpoint signaling; neuron apoptotic process; and protein neddylation. Located in early endosome and membrane raft. Biomarker of middle cerebral artery infarction. Orthologous to human NAE1 (NEDD8 activating enzyme E1 subunit 1). [provided by Alliance of Genome Resources, Apr 2022]