Wfs1 - wolframin ER transmembrane glycoprotein

Enables several functions, including calmodulin binding activity; proteasome binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of ATF6-mediated unfolded protein response; protein stabilization; and regulation of transcription, DNA-templated. Is integral component of synaptic vesicle membrane. Used to study cataract; diabetes mellitus; and glucose intolerance. Biomarker of post-traumatic stress disorder and visual epilepsy. Human ortholog(s) of this gene implicated in Wolfram syndrome (multiple); auditory system disease (multiple); cataract 41; diabetes mellitus (multiple); and optic atrophy (multiple). Orthologous to human WFS1 (wolframin ER transmembrane glycoprotein). [provided by Alliance of Genome Resources, Apr 2022]