Akr1c6 - aldo-keto reductase family 1, member C6

Enables estradiol 17-beta-dehydrogenase activity. Acts upstream of or within negative regulation of mRNA splicing, via spliceosome and steroid metabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; liver and biliary system; lung; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to several human genes including AKR1C1 (aldo-keto reductase family 1 member C1) and AKR1C3 (aldo-keto reductase family 1 member C3). [provided by Alliance of Genome Resources, Apr 2022]