Defb1 - defensin beta 1

Predicted to enable CCR6 chemokine receptor binding activity; double-stranded DNA binding activity; and identical protein binding activity. Involved in acute inflammatory response and response to testosterone. Predicted to be located in microvesicle and sperm midpiece. Predicted to be extrinsic component of membrane. Predicted to be active in extracellular space. Biomarker of obesity and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and lung disease. Orthologous to human DEFB1 (defensin beta 1). [provided by Alliance of Genome Resources, Apr 2022]