Slc12a2 - solute carrier family 12 member 2

Enables sodium:potassium:chloride symporter activity. Involved in several processes, including chloride transport; metal ion transport; and positive regulation of cell volume. Acts upstream of or within gamma-aminobutyric acid signaling pathway and regulation of spontaneous synaptic transmission. Located in cytosol and plasma membrane. Used to study hypertension; middle cerebral artery infarction; and visual epilepsy. Biomarker of hypertension; sensorineural hearing loss; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 78. Orthologous to human SLC12A2 (solute carrier family 12 member 2). [provided by Alliance of Genome Resources, Apr 2022]