Nefl - neurofilament light chain

Enables phospholipase binding activity and protein domain specific binding activity. Involved in several processes, including central nervous system development; intermediate filament cytoskeleton organization; and response to corticosterone. Located in growth cone and neurofilament. Colocalizes with neuron projection. Used to study congenital hypothyroidism. Biomarker of hypothyroidism; mental depression; sciatic neuropathy; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease (multiple); amyotrophic lateral sclerosis; and invasive ductal carcinoma. Orthologous to human NEFL (neurofilament light chain). [provided by Alliance of Genome Resources, Apr 2022]