Cdkn1b - cyclin-dependent kinase inhibitor 1B

Enables Hsp70 protein binding activity and chaperone binding activity. Involved in several processes, including regulation of cyclin-dependent protein serine/threonine kinase activity; response to estradiol; and response to glucose. Located in cytoplasm and nucleus. Part of protein-containing complex. Used to study cataract; endocrine organ benign neoplasm (multiple); infertility; multiple endocrine neoplasia; and myocardial infarction. Biomarker of several diseases, including acute kidney failure; glomerulonephritis (multiple); obesity; pulmonary hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in acute myeloid leukemia; breast cancer; multiple endocrine neoplasia type 4; and myelodysplastic syndrome. Orthologous to human CDKN1B (cyclin dependent kinase inhibitor 1B). [provided by Alliance of Genome Resources, Apr 2022]