Thra - thyroid hormone receptor alpha

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; nucleic acid binding activity; and protein homodimerization activity. Involved in several processes, including animal organ development; digestive tract development; and regulation of transcription, DNA-templated. Located in cytosol; mitochondrion; and nucleus. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 6 and renal cell carcinoma. Orthologous to human THRA (thyroid hormone receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]