Pdpk1 - 3-phosphoinositide dependent protein kinase-1

Enables 3-phosphoinositide-dependent protein kinase activity; insulin receptor binding activity; and protein kinase binding activity. Involved in cellular response to brain-derived neurotrophic factor stimulus; focal adhesion assembly; and negative regulation of neuron apoptotic process. Located in cytosol; perikaryon; and plasma membrane. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to several human genes including PDPK1 (3-phosphoinositide dependent protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]