P2rx3 - purinergic receptor P2X 3

Enables several functions, including ATP binding activity; extracellularly ATP-gated cation channel activity; and identical protein binding activity. Involved in several processes, including behavioral response to formalin induced pain; neuronal action potential; and positive regulation of sensory perception of pain. Located in several cellular components, including dendritic spine; membrane raft; and rough endoplasmic reticulum. Is integral component of plasma membrane. Is integral component of presynaptic membrane. Orthologous to human P2RX3 (purinergic receptor P2X 3). [provided by Alliance of Genome Resources, Apr 2022]