Jup - junction plakoglobin

Enables protein kinase binding activity. Predicted to be involved in several processes, including cellular response to indole-3-methanol; regulation of heart contraction; and regulation of transcription, DNA-templated. Predicted to act upstream of or within cell-cell adhesion; desmosome assembly; and skin development. Located in several cellular components, including apicolateral plasma membrane; fascia adherens; and lateral plasma membrane. Colocalizes with actin cytoskeleton. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); palmoplantar keratosis (multiple); renal cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human JUP (junction plakoglobin). [provided by Alliance of Genome Resources, Apr 2022]