Enables calmodulin-dependent protein kinase activity; inositol-1,4,5-trisphosphate 3-kinase activity; and small GTPase binding activity. Acts upstream of or within actin cytoskeleton organization; dendritic spine maintenance; and positive regulation of dendritic spine morphogenesis. Located in dendritic spine. Orthologous to human ITPKA (inositol-trisphosphate 3-kinase A). [provided by Alliance of Genome Resources, Apr 2022]