Enables histamine N-methyltransferase activity. Involved in several processes, including hyperosmotic response; response to cocaine; and response to interleukin-1. Located in neuron projection. Used to study brain infarction. Human ortholog(s) of this gene implicated in Parkinson's disease; asthma; atopic dermatitis; autosomal recessive non-syndromic intellectual disability; and essential tremor. Orthologous to human HNMT (histamine N-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]