Grm7 - glutamate metabotropic receptor 7

Enables several functions, including PDZ domain binding activity; calmodulin binding activity; and glutamate binding activity. Involved in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; negative regulation of glutamate secretion; and negative regulation of neuron apoptotic process. Located in several cellular components, including dendritic shaft; rough endoplasmic reticulum; and synaptic membrane. Part of protein-containing complex. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of presynaptic active zone membrane. Orthologous to human GRM7 (glutamate metabotropic receptor 7). [provided by Alliance of Genome Resources, Apr 2022]