Smad7 - SMAD family member 7

Enables ubiquitin protein ligase binding activity. Involved in intracellular signal transduction; negative regulation of transcription, DNA-templated; and regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in several cellular components, including centrosome; cytosol; and nuclear lumen. Predicted to be part of heteromeric SMAD protein complex. Predicted to colocalize with adherens junction. Biomarker of nephritis and pulmonary hypertension. Human ortholog(s) of this gene implicated in colorectal cancer and pancreatic adenocarcinoma. Orthologous to human SMAD7 (SMAD family member 7). [provided by Alliance of Genome Resources, Apr 2022]