Bdkrb1 - bradykinin receptor B1

Enables bradykinin receptor activity and peptide binding activity. Involved in several processes, including positive regulation of release of sequestered calcium ion into cytosol; protein kinase C-activating G protein-coupled receptor signaling pathway; and response to lipopolysaccharide. Located in neuron projection and plasma membrane. Used to study diabetic angiopathy; epilepsy; hypertension; neuropathy (multiple); and pleurisy. Biomarker of diabetic retinopathy; hypertension; and myocardial infarction. Human ortholog(s) of this gene implicated in end stage renal disease; hypertension; and pulmonary fibrosis. Orthologous to human BDKRB1 (bradykinin receptor B1). [provided by Alliance of Genome Resources, Apr 2022]