Polh - polymerase (DNA directed), eta (RAD 30 related)

Enables DNA-directed DNA polymerase activity. Acts upstream of or within cellular response to UV-C; postreplication repair; and pyrimidine dimer repair. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus; replication fork; and site of double-strand break. Is expressed in several structures, including genitourinary system; heart; hemolymphoid system gland; liver; and lung. Used to study xeroderma pigmentosum variant type. Human ortholog(s) of this gene implicated in xeroderma pigmentosum variant type. Orthologous to human POLH (DNA polymerase eta). [provided by Alliance of Genome Resources, Apr 2022]