Hspb8 - heat shock protein 8

Predicted to enable protein homodimerization activity. Predicted to be involved in cellular response to unfolded protein and positive regulation of aggrephagy. Predicted to be located in cytosol and nuclear body. Predicted to be part of chaperone complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study distal hereditary motor neuronopathy type 2A. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2L and distal hereditary motor neuronopathy type 2A. Orthologous to human HSPB8 (heat shock protein family B (small) member 8). [provided by Alliance of Genome Resources, Apr 2022]