Hsd17b4 - hydroxysteroid (17-beta) dehydrogenase 4

Enables 17-beta-hydroxysteroid dehydrogenase (NAD+) activity; 3-hydroxyacyl-CoA dehydratase activity; and identical protein binding activity. Involved in several processes, including aging; cellular response to organic cyclic compound; and response to steroid hormone. Located in peroxisome. Biomarker of hypertension. Human ortholog(s) of this gene implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome. Orthologous to human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4). [provided by Alliance of Genome Resources, Apr 2022]