Hmgcl - 3-hydroxy-3-methylglutaryl-CoA lyase

Enables carboxylic acid binding activity; fatty-acyl-CoA binding activity; and hydroxymethylglutaryl-CoA lyase activity. Involved in several processes, including acyl-CoA metabolic process; ketone body biosynthetic process; and liver development. Located in mitochondrion. Human ortholog(s) of this gene implicated in amino acid metabolic disorder. Orthologous to human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase). [provided by Alliance of Genome Resources, Apr 2022]