Tnfrsf22 - tumor necrosis factor receptor superfamily, member 22

Enables TRAIL binding activity. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. Located in external side of plasma membrane. Is expressed in embryo; heart; liver; placenta; and trunk. Human ortholog(s) of this gene implicated in carcinoma (multiple); cervical cancer; hematologic cancer (multiple); and urinary bladder cancer. Orthologous to human TNFRSF10A (TNF receptor superfamily member 10a) and TNFRSF10C (TNF receptor superfamily member 10c). [provided by Alliance of Genome Resources, Apr 2022]