Apaf1 - apoptotic peptidase activating factor 1

Enables heat shock protein binding activity and identical protein binding activity. Involved in several processes, including animal organ development; cardiac muscle cell apoptotic process; and cellular response to transforming growth factor beta stimulus. Located in cytoplasm. Part of apoptosome. Used to study visual epilepsy. Biomarker of brain ischemia; colon cancer; middle cerebral artery infarction; and muscular atrophy. Orthologous to human APAF1 (apoptotic peptidase activating factor 1). [provided by Alliance of Genome Resources, Apr 2022]