Enables natural killer cell lectin-like receptor binding activity. Acts upstream of or within several processes, including positive regulation of immune response; positive regulation of interferon-gamma production; and positive regulation of leukocyte activation. Located in external side of plasma membrane. Is integral component of plasma membrane. Orthologous to several human genes including ULBP1 (UL16 binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]