Prdm8 - PR domain containing 8

Enables chromatin binding activity; histone methyltransferase activity (H3-K9 specific); and transcription corepressor activity. Acts upstream of or within central nervous system projection neuron axonogenesis; histone H3-K9 methylation; and negative regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; lung; retina; and testis. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 10. Orthologous to human PRDM8 (PR/SET domain 8). [provided by Alliance of Genome Resources, Apr 2022]