Rapgef2 - Rap guanine nucleotide exchange factor (GEF) 2

Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including cAMP-mediated signaling; cellular response to cAMP; and generation of neurons. Predicted to be located in several cellular components, including apical plasma membrane; bicellular tight junction; and cytoplasmic vesicle. Predicted to be part of protein-containing complex. Is expressed in embryo; olfactory epithelium; yolk sac endoderm; and yolk sac mesenchyme. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 7. Orthologous to human RAPGEF2 (Rap guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Apr 2022]