Smurf1 - SMAD specific E3 ubiquitin protein ligase 1

Predicted to enable I-SMAD binding activity; R-SMAD binding activity; and ubiquitin protein ligase activity. Involved in parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization. Acts upstream of or within negative regulation of ossification and protein ubiquitination. Predicted to be located in axon; neuronal cell body; and plasma membrane. Predicted to be active in cytoplasm. Predicted to colocalize with mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and respiratory system. Orthologous to human SMURF1 (SMAD specific E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Apr 2022]