Sirt4 - sirtuin 4

Enables NAD+ ADP-ribosyltransferase activity; NAD-dependent protein deacetylase activity; and lipoamidase activity. Involved in several processes, including carboxylic acid metabolic process; cellular protein modification process; and regulation of cellular ketone metabolic process. Acts upstream of or within negative regulation of insulin secretion. Located in mitochondrial inner membrane and mitochondrial matrix. Is expressed in several structures, including gonad; heart; nervous system; respiratory system; and thyroid gland. Orthologous to human SIRT4 (sirtuin 4). [provided by Alliance of Genome Resources, Apr 2022]