Traf3ip1 - TRAF3 interacting protein 1

Predicted to enable microtubule binding activity and signaling receptor binding activity. Involved in morphogenesis of a polarized epithelium and regulation of microtubule cytoskeleton organization. Acts upstream of or within several processes, including embryonic organ development; negative regulation of interferon-beta production; and negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning. Located in axoneme; centrosome; and ciliary basal body. Part of intraciliary transport particle B. Is expressed in genitourinary system and nose. Human ortholog(s) of this gene implicated in Senior-Loken syndrome. Orthologous to human TRAF3IP1 (TRAF3 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]