Sppl2b - signal peptide peptidase like 2B

Predicted to enable aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Predicted to be involved in membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; and regulation of immune response. Predicted to be located in several cellular components, including cytoskeleton; endosome membrane; and nucleoplasm. Predicted to be active in Golgi-associated vesicle membrane and lysosomal membrane. Predicted to be integral component of cytoplasmic side of endoplasmic reticulum membrane and integral component of lumenal side of endoplasmic reticulum membrane. Is expressed in embryo. Orthologous to human SPPL2B (signal peptide peptidase like 2B). [provided by Alliance of Genome Resources, Apr 2022]