Fezf1 - Fez family zinc finger 1

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell dedifferentiation; nervous system development; and regulation of transcription, DNA-templated. Acts upstream of or within nervous system development and positive regulation of neuron differentiation. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including brain and nose. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 22 with or without anosmia. Orthologous to human FEZF1 (FEZ family zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]