Enables signaling receptor binding activity. Acts upstream of or within transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; heart; intraembryonic coelom; limb mesenchyme; and skeleton. Orthologous to human ANGPTL1 (angiopoietin like 1). [provided by Alliance of Genome Resources, Apr 2022]