Uaca - uveal autoantigen with coiled-coil domains and ankyrin repeats

Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway; negative regulation of NIK/NF-kappaB signaling; and positive regulation of protein import into nucleus. Located in several cellular components, including cytosol; nuclear envelope; and perinuclear region of cytoplasm. Part of apoptosome. Is expressed in several structures, including cerebral cortex ventricular layer; genitourinary system; heart; liver; and lung. Used to study hepatocellular carcinoma. Orthologous to human UACA (uveal autoantigen with coiled-coil domains and ankyrin repeats). [provided by Alliance of Genome Resources, Apr 2022]