Ercc8 - excision repaiross-complementing rodent repair deficiency, complementation group 8

Predicted to contribute to ubiquitin-protein transferase activity. Acts upstream of or within response to UV and response to X-ray. Predicted to be located in cytoplasm; nuclear matrix; and perikaryon. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex and nucleotide-excision repair complex. Used to study Cockayne syndrome. Human ortholog(s) of this gene implicated in Cockayne syndrome; Cockayne syndrome A; and UV-sensitive syndrome. Orthologous to human ERCC8 (ERCC excision repair 8, CSA ubiquitin ligase complex subunit). [provided by Alliance of Genome Resources, Apr 2022]