Epgn - epithelial mitogen

Enables epidermal growth factor receptor binding activity and growth factor activity. Involved in positive regulation of epidermal growth factor-activated receptor activity; positive regulation of epithelial cell proliferation; and positive regulation of mitotic nuclear division. Acts upstream of or within MAPK cascade. Predicted to be integral component of plasma membrane. Predicted to be active in extracellular space. Is expressed in alimentary system; male reproductive gland or organ; metanephros; and skin. Orthologous to human EPGN (epithelial mitogen). [provided by Alliance of Genome Resources, Apr 2022]