Predicted to enable ubiquitin protein ligase binding activity and ubiquitin-protein transferase activity. Acts upstream of or within protein catabolic process. Located in nucleolus. Part of Cul2-RING ubiquitin ligase complex. Is expressed in cervical ganglion; cervico-thoracic ganglion; dorsal root ganglion; thoracic ganglion; and trigeminal ganglion. Orthologous to human CUL2 (cullin 2). [provided by Alliance of Genome Resources, Apr 2022]