Vps11 - VPS11, CORVET/HOPS core subunit

Predicted to enable several functions, including protein-macromolecule adaptor activity; syntaxin binding activity; and ubiquitin protein ligase activity. Acts upstream of or within toxin transport. Located in actin filament; early endosome; and presynaptic active zone. Part of AP-3 adaptor complex and CORVET complex. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 12. Orthologous to human VPS11 (VPS11 core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Apr 2022]