Optn - optineurin

Enables K63-linked polyubiquitin modification-dependent protein binding activity. Acts upstream of or within cellular protein localization and negative regulation of I-kappaB kinase/NF-kappaB signaling. Located in perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; eye; genitourinary system; musculoskeletal system; and nervous system. Human ortholog(s) of this gene implicated in Paget's disease of bone; amyotrophic lateral sclerosis (multiple); and glaucoma (multiple). Orthologous to human OPTN (optineurin). [provided by Alliance of Genome Resources, Apr 2022]