Enables protein-cysteine S-palmitoyltransferase activity. Involved in antiviral innate immune response; peptidyl-L-cysteine S-palmitoylation; and positive regulation of defense response to virus by host. Located in endosome membrane. Is expressed in brain; male reproductive gland or organ; metanephros; and submandibular gland. Orthologous to several human genes including ZDHHC11 (zinc finger DHHC-type containing 11). [provided by Alliance of Genome Resources, Apr 2022]