Enables protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including antiviral innate immune response; peptidyl-L-cysteine S-palmitoylation; and positive regulation of defense response to virus by host. Acts upstream of or within protein palmitoylation. Located in endosome membrane. Is expressed in several structures, including adrenal gland; brain; genitourinary system; heart; and lung. Orthologous to human ZDHHC1 (zinc finger DHHC-type containing 1). [provided by Alliance of Genome Resources, Apr 2022]