Ubr5 - ubiquitin protein ligase E3 component n-recognin 5

Predicted to enable protein domain specific binding activity and ubiquitin-ubiquitin ligase activity. Acts upstream of or within negative regulation of interleukin-17 production and regulation of protein stability. Predicted to be located in cytosol; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in cranial ganglion; nervous system; sensory organ; submandibular gland primordium; and vibrissa. Human ortholog(s) of this gene implicated in invasive ductal carcinoma. Orthologous to human UBR5 (ubiquitin protein ligase E3 component n-recognin 5). [provided by Alliance of Genome Resources, Apr 2022]