Polr3b - polymerase (RNA) III (DNA directed) polypeptide B

Predicted to enable several functions, including DNA binding activity; metal ion binding activity; and ribonucleoside binding activity. Predicted to contribute to DNA-directed 5'-3' RNA polymerase activity. Predicted to be involved in positive regulation of innate immune response and positive regulation of interferon-beta production. Predicted to act upstream of or within defense response to virus and innate immune response. Predicted to be located in nucleus. Predicted to be part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadism. Orthologous to human POLR3B (RNA polymerase III subunit B). [provided by Alliance of Genome Resources, Apr 2022]