Trim32 - tripartite motif-containing 32

Enables several functions, including identical protein binding activity; translation initiation factor binding activity; and ubiquitin protein ligase activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of cell differentiation; and response to tumor necrosis factor. Acts upstream of or within several processes, including positive regulation of cytokine-mediated signaling pathway; positive regulation of macromolecule metabolic process; and protein ubiquitination. Located in nucleus and striated muscle myosin thick filament. Is expressed in genitourinary system. Used to study autosomal recessive limb-girdle muscular dystrophy type 2H. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 11; autosomal recessive limb-girdle muscular dystrophy type 2H; and muscular dystrophy. Orthologous to human TRIM32 (tripartite motif containing 32). [provided by Alliance of Genome Resources, Apr 2022]