Dapk1 - death associated protein kinase 1

Enables ATP binding activity; calmodulin binding activity; and protein kinase activity. Involved in several processes, including cellular response to interferon-gamma; protein phosphorylation; and regulation of NMDA receptor activity. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors and negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. Located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; liver and biliary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in urinary bladder cancer. Orthologous to human DAPK1 (death associated protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]