Nlrp1b - NLR family, pyrin domain containing 1B

Predicted to enable several functions, including peptidase activator activity; protein domain specific binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including negative regulation of signal transduction; protein-containing complex assembly; and regulation of gene expression. Predicted to be located in nucleoplasm. Predicted to be part of CARD8 inflammasome complex and NLRP3 inflammasome complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in inflammatory bowel disease 30. Orthologous to human CARD8 (caspase recruitment domain family member 8). [provided by Alliance of Genome Resources, Apr 2022]