Snx5 - sorting nexin 5

Predicted to enable D1 dopamine receptor binding activity; dynactin binding activity; and phosphatidylinositol phosphate binding activity. Predicted to be involved in several processes, including positive regulation of renal sodium excretion; regulation of signal transduction; and retrograde transport, endosome to Golgi. Predicted to act upstream of or within endocytosis and protein transport. Predicted to be located in several cellular components, including brush border; macropinocytic cup; and tubular endosome. Predicted to be extrinsic component of cytoplasmic side of plasma membrane and extrinsic component of endosome membrane. Predicted to be part of retromer complex. Predicted to be active in endosome. Predicted to colocalize with early endosome membrane. Is expressed in several structures, including alimentary system; brain; cranium; genitourinary system; and sensory organ. Orthologous to human SNX5 (sorting nexin 5). [provided by Alliance of Genome Resources, Apr 2022]