Spen - spen family transcriptional repressor

Predicted to enable several functions, including DNA-binding transcription factor activity; nucleic acid binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of neurogenesis. Predicted to act upstream of or within negative regulation of transcription, DNA-templated and positive regulation of transcription, DNA-templated. Predicted to be located in nucleoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Orthologous to human SPEN (spen family transcriptional repressor). [provided by Alliance of Genome Resources, Apr 2022]