Kdf1 - keratinocyte differentiation factor 1

Involved in several processes, including positive regulation of epidermal cell differentiation; regulation of epidermal cell division; and skin development. Acts upstream of or within keratinocyte development and negative regulation of keratinocyte proliferation. Located in cell cortex; cell junction; and cell leading edge. Is expressed in several structures, including alimentary system; choroid plexus; lower urinary tract; olfactory epithelium; and pituitary gland. Human ortholog(s) of this gene implicated in ectodermal dysplasia 12. Orthologous to human KDF1 (keratinocyte differentiation factor 1). [provided by Alliance of Genome Resources, Apr 2022]