Smurf1 - SMAD specific E3 ubiquitin protein ligase 1

Predicted to enable I-SMAD binding activity; R-SMAD binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including autophagosome assembly; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within negative regulation of ossification. Located in axon and neuronal cell body. Orthologous to human SMURF1 (SMAD specific E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Apr 2022]