Prrt2 - proline-rich transmembrane protein 2

Enables syntaxin-1 binding activity. Involved in negative regulation of SNARE complex assembly; negative regulation of short-term synaptic potentiation; and synaptic vesicle exocytosis. Located in axon terminus; presynaptic membrane; and synaptic vesicle. Is active in glutamatergic synapse. Is integral component of presynaptic membrane. Is expressed in brain. Used to study episodic kinesigenic dyskinesia 1. Human ortholog(s) of this gene implicated in benign familial neonatal epilepsy and episodic kinesigenic dyskinesia 1. Orthologous to human PRRT2 (proline rich transmembrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]