Setdb1 - SET domain bifurcated histone lysine methyltransferase 1

Predicted to enable DNA binding activity; histone methyltransferase activity (H3-K9 specific); and promoter-specific chromatin binding activity. Involved in response to ethanol and response to vitamin. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autistic disorder and lung cancer. Orthologous to human SETDB1 (SET domain bifurcated histone lysine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]